Pick Your Community: | Hopkins | Muhlenberg | Daviess | Christian | Henderson | Lakes | McCracken | Webster
Davis Motor Sales banner ad

UK Study Shows Potential New Way to Detect Colorectal and Other Cancers

uk medical medicineLEXINGTON, Ky. (4/27/13)— A unique new study led by University of Kentucky Markey Cancer Center researchers Guo-Min Li and Libya Gu, in collaboration with Dr. Wei Yang at National Institutes of Health, reveals a novel mechanism explaining the previously unknown root cause of some forms of colorectal cancers.
 
The study, published in Cell, discovers that an abnormal histone protein modification impairs a DNA repair machinery that controls cancer development, yielding a potential new way of detecting these types of colorectal cancers. It represents the first time that epigenetic histone marks regulate the genome maintenance system.
 
DNA errors created during DNA replication can lead to many forms of cancer, including colorectal cancer. Cells possess DNA mismatch repair (MMR) machinery that aids in correcting these errors, thus preventing disease development. Defects in MMR genes lead to development of colorectal cancers characterized by frequent alterations in simple repetitive DNA sequences, a phenomenon referred to as microsatellite instability (MSI). Some cancers develop in individuals who possess MSI without MMR gene defects, and until now, the reason for this has been unknown.
 
Dr. Li’s study shows that defects in SETD2 – an enzyme that is not involved in MMR but chemically or epigenetically modifies histone proteins associated with DNA that control the regulation of gene expression and DNA replication – prevent the association of MMR proteins with damaged DNA, thus preventing DNA mismatch repair.
 
"This study provides new clues to cancer etiology, that is, from the classical genetic defects to abnormal epigenetic modifications in the future," Li said. "Since SETD2 mutations have been shown in many types of cancers, including clear cell renal cell carcinoma, lung cancer, gastric cancer and hematological malignancies, our next goal is to determine association of MMR defects with these cancers, as well as SETD2 mutations in MSI-positive MMR-competent colorectal cancers."
 
Although most colorectal cancers are preventable or treatable with proper screening, colorectal cancer remains the second-leading cause of cancer death in the United States. Kentucky is ranked in the highest tiers for both colorectal and lung cancer incidence and death.

SurfKY News
Information provided by Allison Perry
Photo provided by the University of Kentucky

© Copyright 2014 SurfKY News Group, Inc. All rights reserved. This material may not be published, broadcast, or rewritten without permission. SurfKY News encourages you to share this story by using one of the social media links below.

Posted on 2/2/14

Latest Video

Genovese - http://www.mchky.org/staff/bio.php?doc_id=35646&sub= Lewis - http://www.mchky.org/getpage.php?name=bracken_lewis Holt - http://www.mchky.org/getpage.php?name=drholt Napier - http://www.mchky.org/getpage.php?name=dr.napier_page Newman - http://www.mchky.org/staff/bio.php?doc_id=50353
Genovese - http://www.mchky.org/staff/bio.php?doc_id=35646&sub= Lewis - http://www.mchky.org/getpage.php?name=bracken_lewis Holt - http://www.mchky.org/getpage.php?name=drholt Napier - http://www.mchky.org/getpage.php?name=dr.napier_page Newman - http://www.mchky.org/staff/bio.php?doc_id=50353
3/12 - 718 switched from reg 2 to hopkins only
2/6/2014 - posted
3/13 - 16
Started 11/8/2013
Started 11/8/2013

Stock Report

1 DOW 17,098.45
+18.88 (0.11%)    
2 S&P 2,003.37
+6.63 (0.33%)    
3 NASDAQ 4,580.27
+22.58 (0.50%)    
Genovese - http://www.mchky.org/staff/bio.php?doc_id=35646&sub= Lewis - http://www.mchky.org/getpage.php?name=bracken_lewis Holt - http://www.mchky.org/getpage.php?name=drholt Napier - http://www.mchky.org/getpage.php?name=dr.napier_page Newman - http://www.mchky.org/staff/bio.php?doc_id=50353
Genovese - http://www.mchky.org/staff/bio.php?doc_id=35646&sub= Lewis - http://www.mchky.org/getpage.php?name=bracken_lewis Holt - http://www.mchky.org/getpage.php?name=drholt Napier - http://www.mchky.org/getpage.php?name=dr.napier_page Newman - http://www.mchky.org/staff/bio.php?doc_id=50353
3/12 - 718 switched from reg 2 to hopkins only
2/6/2014 - posted
3/13 - 16
Started 11/8/2013
Started 11/8/2013
Genovese - http://www.mchky.org/staff/bio.php?doc_id=35646&sub= Lewis - http://www.mchky.org/getpage.php?name=bracken_lewis Holt - http://www.mchky.org/getpage.php?name=drholt Napier - http://www.mchky.org/getpage.php?name=dr.napier_page Newman - http://www.mchky.org/staff/bio.php?doc_id=50353
Genovese - http://www.mchky.org/staff/bio.php?doc_id=35646&sub= Lewis - http://www.mchky.org/getpage.php?name=bracken_lewis Holt - http://www.mchky.org/getpage.php?name=drholt Napier - http://www.mchky.org/getpage.php?name=dr.napier_page Newman - http://www.mchky.org/staff/bio.php?doc_id=50353
3/12 - 718 switched from reg 2 to hopkins only
2/6/2014 - posted
3/13 - 16
Started 11/8/2013
Started 11/8/2013
Genovese - http://www.mchky.org/staff/bio.php?doc_id=35646&sub= Lewis - http://www.mchky.org/getpage.php?name=bracken_lewis Holt - http://www.mchky.org/getpage.php?name=drholt Napier - http://www.mchky.org/getpage.php?name=dr.napier_page Newman - http://www.mchky.org/staff/bio.php?doc_id=50353
Genovese - http://www.mchky.org/staff/bio.php?doc_id=35646&sub= Lewis - http://www.mchky.org/getpage.php?name=bracken_lewis Holt - http://www.mchky.org/getpage.php?name=drholt Napier - http://www.mchky.org/getpage.php?name=dr.napier_page Newman - http://www.mchky.org/staff/bio.php?doc_id=50353
3/12 - 718 switched from reg 2 to hopkins only
2/6/2014 - posted
3/13 - 16
Started 11/8/2013
Started 11/8/2013

Most Read This Week (Site-Wide)

August 29, 2014 8055

Luke's Flea Market Vendors' Home Away…

in News by Charles W. Riley II, SurfKY News
August 28, 2014 7403

Police Pursuit Spans Parts of Northern…

in Top Stories by Alex Piper, MCSO
August 30, 2014 7141

One Hospitalized After Officer-Involved…

in Top Stories by Charles W. Riley II, SurfKY News
August 29, 2014 3763

Business Spotlight - Magical Memories…

in Top Stories by Charles W. Riley II, SurfKY News
August 28, 2014 3445

Another Greenville Home Invasion Being…

in Top Stories by Wes Miller, GPD

Most Read Stories from Hopkins County

August 30, 2014 3145

Ponderosa Madisonville to Donate 10…

in Top Stories by Rita Dukes Smith, SurfKY News Director
August 30, 2014 1250

City of Madisonville Says 'Goodbye' to…

in Top Stories by Amber Averitt, SurfKY News
August 29, 2014 864

MCC Announces New Board Members

in Top Stories by Joyce Riggs
August 29, 2014 558

Trover Health Endowment Reaches $100,000…

in Top Stories by Joyce Riggs
August 28, 2014 458

Ceremony Honors Webster County WWII…

in Top Stories by Ami Clayton, SurfKY News

Most Read Stories from Owensboro

August 29, 2014 2397

Daviess County Sheriff’s Office Activity…

in News by Dennis Beard, SurfKY News
August 29, 2014 2333

Owensboro Police Department Activity…

in News by Dennis Beard, SurfKY News
August 28, 2014 1991

Downtown Trolley to Run on Labor Day

in News by Abby Shelton
August 30, 2014 1445

Owensboro Traffic Advisory

in News by Keith Todd
August 28, 2014 1252

Daviess County Sheriff’s Office Activity…

in News by Dennis Beard, SurfKY News

Most Read Stories from Muhlenberg County

August 28, 2014 7403

Police Pursuit Spans Parts of Northern…

in Top Stories by Alex Piper, MCSO
August 29, 2014 3763

Business Spotlight - Magical Memories…

in Top Stories by Charles W. Riley II, SurfKY News
August 28, 2014 3445

Another Greenville Home Invasion Being…

in Top Stories by Wes Miller, GPD
August 28, 2014 2166

Whitfield, Yonts Pay Tribute to Bob and…

in Top Stories by Paul McRee, SurfKY News
August 28, 2014 2073

Stanton Barrett's NASCAR Mustang Gets…

in Top Stories by Charles W. Riley II, SurfKY News

SurfKY News Group, Inc. Central Office & Printing Division
1125 Nebo Rd.  •  Madisonville, KY 42431  •  270.452.2249 (fax)
Main Number: 270.452.2727 (phone)  •  Printing Division Direct Line: 270.821.8600 (phone)

SurfKY Owensboro News Bureau
920 Frederica St. / Suite 210  •  Owensboro, KY 42301  •  270.683-8060 (phone)


Contact a member of our staff: www.surfky.com/contact
Copyright © 2014 SurfKY News Group, Inc.  •  Terms of Use  •  Site Map

social 03social 04social 22social 21social 06