Posted on 2/2/14

shot needle 300LEXINGTON, Ky. (11/5/13) – A study conducted by a group of international researchers has found that taking flu shots can lead to a reduced risk of cardiac 'events'. The results of the study were published in an October in the Journal of the American Medical Association.

The study reports that of 3,238 patients, who received a flu vaccine, 2.9 percent later had a "major cardiac event." But of the 3,231 patients who did not receive a flu shot, 4.7 percent later experienced a major cardiac event, such as a heart attack.

Dr. Charles Campbell is an associate professor of medicine at University of Kentucky HealthCare. Campbell said the study is what is known as a meta-analysis, or taking the results of small studies and lumping them together to get information not available in each of the individual studies.

“Usually what we say about meta-analyses is that in that of themselves, they are really hypothesis generated,” said Campbell. “In other words, they would be the kind of trial you use to go to the NIH (National Institute of Health) and say 'Look, it looks to me like flu shots are going to be very effective at preventing heart attacks, especially on high risk patients. We need to study that.'”

Yet, Campbell adds this study could be a situation where there is not enough interest at the federal level to fund further research, adding that it would be very hard to enroll people in a trial where they would have to not take a flu shot in order to compare them to those of whom do receive a flu shot.

“If you're my 80 year old grandmother, I want you to get your flu shot so you don't get the flu,” said Campbell. “It's going to be really hard for me to say we're going to take 80 year olds in the state of Kentucky and randomize some of them to get the flu shot and some of them not to, because everybody indicated to have the flu shot to have another reason. I don't think a big trial is necessarily going to come rolling out in the next couple years. We may be left with this meta-analysis as the best bit of data we can get.”

But, this isn't necessarily bad news, said Campbell. The information from the study can now be used to further convince patients to receive the flu shot.

“This data is just one more thing I pull out of my bag to help people make an informed decision about the flu shot,” said Campbell. “There is evidence that in addition to preventing the flu, you may be preventing cardiovascular events as well. That's what the evidence is hinting at. So, I view a meta-analysis as a suggestion, not a fact.”

Experts are uncertain as to why flu shots appear to provide increased cardiovascular protection. However, Campbell has a theory.

“I think that we know that acute respiratory infections raise inflammation, and inflammation leads to adverse cardiac events,” he said. “It seems to be, to my mind, to have something to do with that. Now, there were people years ago, who thought maybe the virus was actually related to the event. I don't think anybody has enough information to suggest that.”

Campbell added that he is happy to have this information in order to use it as another tool to promote getting a flu shot.

“There's some biology going on here that's worth understanding, and my guess is it has something to do with inflammation. That's what I tell my patients,” said Campbell. “It's not understood really well. But, if you were on the fence about taking the flu shot, I'd probably go ahead and get it.”

David Gillum
SurfKY News
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