Pick Your Community: | Hopkins | Muhlenberg | Daviess | Christian | Fayette | Henderson | Lakes | McCracken | Warren | Webster

Guo Lab Discovers New Class of Revolution Biomotor and Solves Mystery in Viral DNA Packaging

guo 300LEXINGTON, Ky. (3/21/13) – Scientists at the University of Kentucky have cracked a 35-year-old mystery about the workings of natural "biomotors." These molecular machines are serving as models for development of synthetic nanomotors that will someday pump therapeutic DNA, RNA or drugs into individual diseased cells.
 
The report, revealing the innermost mechanisms of these motors in a bacteria-killing virus and a "new way to move DNA through cells," is being published online today in the journal ACS Nano.
 
The article, "Mechanism of One-Way Traffic of Hexameric Phi29 DNA Packaging Motor with Four Electropositive Relaying Layers Facilitating Anti-Parallel Revolution," can be downloaded with free, open access from http://pubs.acs.org/doi/abs/10.1021/nn4002775.
 
Peixuan Guo, director of the UK Nanobiotechnology Center, and his colleagues explain that two motors have been found in nature: A linear motor and a rotating motor. Now they report discovery of a third type, a revolving molecular motor.
 
Guo points out that nanomotors will open the door to practical machines and other nanotechnology devices so small that 100,000 would fit across the width of a human hair. One major natural prototype for those development efforts has been the motor that packages DNA into the shell of bacteriophage phi29, a virus that infects and kills bacteria.
 
Guo’s own research team wants to embed a synthetic version of that motor into nanomedical devices that are injected into the body, travel to diseased cells and pump in medication. A major barrier in doing so has been uncertainty and controversy about exactly how the phi29 motor moves. Scientists thought that it worked by rotating or spinning in the same motion as the Earth turning once every 24 hours upon its own axis.
 
In their ACS Nano paper, Guo — with his team, Zhengyi Zhao, Emil Khisamutdinov, and Chad Schwartz — challenge that idea. Indeed, they discovered that the phi29 motor moves DNA without any rotational motion. The motor moves DNA with a revolving in the same motion as the Earth revolving around the sun in one orbit ever 365 days. The "revolution without rotation" model could resolve a big conundrum troubling the past 35 years of painstaking investigation of the mechanism of these viral DNA packaging motors, the report states.
 
Guo is professor in the UK College of Pharmacy's Department of Pharmaceutical Sciences and holds the William S. Farish Fund Endowed Chair in Nanobiotechnology for the Markey Cancer Center.
 
The authors acknowledge funding from the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health.
 
Illustrated videos of the mechanism can be found at http://nanobio.uky.edu/movie2013.html
 
SurfKY News
Information provided by Keith Hautala
Photo provided by the University of Kentucky

© Copyright 2014 SurfKY News Group, Inc. All rights reserved. This material may not be published, broadcast, or rewritten without permission. SurfKY News encourages you to share this story by using one of the social media links below.

Most Read This Week (Site-Wide)

July 24, 2014 3756

Powderly Man Injured in Apparent Gun…

in Top Stories by Charles W. Riley II, SurfKY News
July 23, 2014 2732

Crime Stoppers Top Most Wanted - July 23,…

in Top Stories by Crime Stoppers
July 24, 2014 2662

Madisonville Man Charged for Drugs,…

in Top Stories by Trooper Stu Recke
July 23, 2014 2265

Greenville Family Loses Home, Possessions…

in Top Stories by Charles W. Riley II, SurfKY News
July 25, 2014 2071

No One Injured in Truck-Train Collision

in Top Stories by Ami Clayton, SurfKY News

Most Read Stories from Hopkins County

July 23, 2014 2732

Crime Stoppers Top Most Wanted - July 23,…

in Top Stories by Crime Stoppers
July 24, 2014 2662

Madisonville Man Charged for Drugs,…

in Top Stories by Trooper Stu Recke
July 25, 2014 2071

No One Injured in Truck-Train Collision

in Top Stories by Ami Clayton, SurfKY News
July 25, 2014 1354

Vehicle Strikes Lawn Mower Driven on…

in Top Stories by Dep. Mike Evans
July 24, 2014 1047

Hopkins County Fair Provides Family Fun

in Top Stories by Ami Clayton, SurfKY News

Most Read Stories from Owensboro

July 23, 2014 1515

Owensboro Neighborhood Alliance Meeting…

in News by Sherry Girten
July 23, 2014 1458

Fall Baseball League Registrations

in News by Brittni Bunn
July 24, 2014 1288

US 231 Ohio River 'William Natcher'…

in News by Keith Todd
July 24, 2014 968

Maintenance Scheduled at Fisher Park and…

in News by Brittni Bunn
July 24, 2014 823

Portion of Spring Bank Drive Closed…

in News by Sherry Girten

Most Read Stories from Muhlenberg County

July 24, 2014 3756

Powderly Man Injured in Apparent Gun…

in Top Stories by Charles W. Riley II, SurfKY News
July 23, 2014 2265

Greenville Family Loses Home, Possessions…

in Top Stories by Charles W. Riley II, SurfKY News
July 23, 2014 1962

Swinging for Sadie Raises $6,000 for…

in Top Stories by Paul McRee, SurfKY News
July 24, 2014 1696

Muhlenberg to Have State's Only Honey…

in Top Stories by Charles W. Riley II, SurfKY News
July 24, 2014 1256

Marching Mustangs Band Camp Underway

in Top Stories by Charles W. Riley II, SurfKY News

SurfKY News Group, Inc. Central Office & Printing Division
1125 Nebo Rd.  •  Madisonville, KY 42431  •  270.452.2249 (fax)
Main Number: 270.452.2727 (phone)  •  Printing Division Direct Line: 270.821.8600 (phone)

SurfKY Owensboro News Bureau
920 Frederica St. / Suite 210  •  Owensboro, KY 42301  •  270.683-8060 (phone)


Contact a member of our staff: www.surfky.com/contact
Copyright © 2014 SurfKY News Group, Inc.  •  Terms of Use  •  Site Map

social 06social 21social 22social 04social 03