Pick Your Community: | Hopkins | Muhlenberg | Daviess | Christian | Fayette | Henderson | Lakes | McCracken | Warren | Webster

A Genetic Answer to the Alzheimer’s Riddle?

research 500

LEXINGTON, Ky (8/15/13)— What if we could pinpoint a hereditary cause for Alzheimer's, and intervene to reduce the risk of the disease? We may be closer to that goal, thanks to a team at the University of Kentucky. Researchers affiliated with the UK Sanders-Brown Center on Aging have completed new work in Alzheimer's genetics; the research is detailed in a paper published today in the Journal of Neuroscience.

Emerging evidence indicates that, much like in the case of high cholesterol, some Alzheimer's disease risk is inherited while the remainder is environmental. Family and twin studies suggest that about 70 percent of total Alzheimer's risk is hereditary.
 
Recently published studies identified several variations in DNA sequence that each modify Alzheimer's risk. In their work, the UK researchers investigated how one of these sequence variations may act. They found that a "protective" genetic variation near a gene called CD33 correlated strongly with how the CD33 mRNA was assembled in the human brain. The authors found that a form of CD33 that lacked a critical functional domain correlates with reduced risk of Alzheimers disease. CD33 is thought to inhibit clearance of amyloid beta, a hallmark of Alzheimers disease.
 
The results obtained by the UK scientists indicate that inhibiting CD33 may reduce Alzheimer's risk. A drug tested for acute myeloid leukemia targets CD33, suggesting the potential for treatments based on CD33 to mitigate the risk for Alzheimer's disease. Additional studies must be conducted before this treatment approach could be tested in humans.
 
Authors on the paper, titled "CD33 Alzheimer's Risk-Altering Polymorphism, CD33 Expression, and Exon 2 Splicing" are Manasi Malik (lead author), Steven Estus, James F. Simpson, and Ishiti Parikh, all of the UK Department of Physiology; Bernard R. Wilfred and Peter Nelson of the UK Department of Pathology, and David W. Fardo of the UK Department of Biostatistics.

SurfKY News
Information provided by Allison Elliott-Shannon

© Copyright 2014 SurfKY News Group, Inc. All rights reserved. This material may not be published, broadcast, or rewritten without permission. SurfKY News encourages you to share this story by using one of the social media links below.

Most Read This Week (Site-Wide)

July 28, 2014 2891

Madisonville Woman Arrested for Being a…

in Top Stories by Madisonville Police Department
July 28, 2014 2469

Madisonville Man Arrested for Endangering…

in Top Stories by Madisonville Police Department
July 25, 2014 2289

No One Injured in Truck-Train Collision

in Top Stories by Ami Clayton, SurfKY News
July 28, 2014 2013

Disagreement Over Killing Snake in House…

in Top Stories by Madisonville Police Department
July 25, 2014 1596

Business Spotlight - McQuady's Automotive

in Top Stories by Charles W. Riley II, SurfKY News

Most Read Stories from Hopkins County

July 28, 2014 2891

Madisonville Woman Arrested for Being a…

in Top Stories by Madisonville Police Department
July 28, 2014 2469

Madisonville Man Arrested for Endangering…

in Top Stories by Madisonville Police Department
July 25, 2014 2289

No One Injured in Truck-Train Collision

in Top Stories by Ami Clayton, SurfKY News
July 28, 2014 2013

Disagreement Over Killing Snake in House…

in Top Stories by Madisonville Police Department
July 28, 2014 1515

Two Injured in Vehicle Collision on…

in Top Stories by William Roundtree

Most Read Stories from Owensboro

July 28, 2014 903

Zuberer Takes Over at Quarterback for…

in News by Steve LeMaster
July 28, 2014 826

Dont Miss Out on a Howl of a Good Time

in News by Brittni Bunn
July 28, 2014 623

Instant Admissions Day is Aug. 1, 2014

in News by Bernie Hale
July 28, 2014 344

Prosecutors Mull Over Whether to Charge…

in Top Stories by Dennis Beard, SurfKY News
July 28, 2014 237

Owensboro Police Department Activity…

in Top Stories by Dennis Beard, SurfKY News

Most Read Stories from Muhlenberg County

July 25, 2014 1596

Business Spotlight - McQuady's Automotive

in Top Stories by Charles W. Riley II, SurfKY News
July 25, 2014 1393

Business Spotlight - Blue Moon Car Wash

in Top Stories by Charles W. Riley II, SurfKY News
July 28, 2014 1087

Foot Pursuit Ends with Arrest

in Top Stories by Christopher Rogers
July 25, 2014 1030

Open Mic, Bike Night Offer Good Times in…

in Top Stories by Paul McRee, SurfKY News
July 28, 2014 1012

Boys of Broad to Launch Video at Cinema 4

in Top Stories by Paul McRee, SurfKY News

SurfKY News Group, Inc. Central Office & Printing Division
1125 Nebo Rd.  •  Madisonville, KY 42431  •  270.452.2249 (fax)
Main Number: 270.452.2727 (phone)  •  Printing Division Direct Line: 270.821.8600 (phone)

SurfKY Owensboro News Bureau
920 Frederica St. / Suite 210  •  Owensboro, KY 42301  •  270.683-8060 (phone)


Contact a member of our staff: www.surfky.com/contact
Copyright © 2014 SurfKY News Group, Inc.  •  Terms of Use  •  Site Map

social 06social 21social 22social 04social 03