megan 2LEXINGTON, KY (10/2/12) – Biology Professor Ann Morris' lab contains approximately 200 individual fish tanks, but only one type of fish.
 
Having recently secured a $1 million grant from the National Institutes of Health (NIH), Morris will continue investigating zebrafish and the insight they offer in regard to solutions for human retinal degeneration. The NIH grant, titled, “The role of insm1 in vertebrate photoreceptor differentiation,” will be funded over five years and focuses on zebrafish to better understand genetic pathways that control the development of the retina.
 
"Mammals cannot regenerate photoreceptors, because the retina is part of the central nervous system, and like other neurons in the brain, when you damage them you can't replace them," Morris said. "So that means when people get genetic diseases where the neurons, particularly the photoreceptors, start to die or to degenerate, there's no way of replacing those cells, so eventually they go blind. While that's true for mammals, it's not true for fish. Fish can regenerate photoreceptors."
 
Morris' study focuses on both the development of the retina and photoreceptor regeneration in fish, as she hopes to gain insight that could eventually be applied to the development of cell-based therapies for human retinal regeneration.
 
"One reason that we can do this, say that what we learn about fish will help humans, is because the structure of the retina and types of cells that you find there are very well conserved between fish and humans," Morris said. "That means that throughout evolution in all of the vertebrates, to which fish and humans both belong, there is a very similar structure to the retina. The same types of cells are found in the retina and the same types of genes control its development in both species. So what we learn in a fish can potentially be applied to what we know about humans."
 
Morris began her work with photoreceptor cells in fish before coming to UK. Using a technique called gene expression profiling, she identified a list of genes to investigate in regard to their role in photoreceptor regeneration. Once at UK, she and her students began working through this list to determine which genes were influential in the production of photoreceptors.
 
"We are particularly focusing on a gene named 'insulinoma-associated 1,' or insm1," Morris said. "We have recently shown that it plays a role in photoreceptor developments, and this grant will allow us to investigate its precise function further and to learn more about all the genes regulated by Insm1 that are also required in making photoreceptors."
 
The grant will also allow Morris, in collaboration with a lab at Northwestern University, to extend the study to mice and determine if insm1 is interacting with the same genes to make mouse photoreceptors. This would bring the study one step closer to human implications, because mice are also mammals.
 
Morris said that both graduate and undergraduate students will have opportunities to conduct this research. Her lab currently hosts four graduate students, one of whom primarily focuses on this specific study. Each semester, undergraduate students also have the option to gain elective research credit through projects in the lab, working closely with the graduate students.
 
"I think it is important to stress that this work is not just mine, and that what we do is very much a team-based approach," Morris said. "My professional success is really interdependent with that of my graduate students and the other people in the lab. I may generate the ideas or come up with an overall research plan, but it is actually in very large part the graduate students and the undergraduate students as they work with the technicians in the lab who are actually doing most of the actual research."
 
The funding period began on Aug. 1, 2012. Morris said she is very excited to see the findings that her lab unveils.
 

 


SurfKY News
Information provided by the University of Kentucky

e-max.it: your social media marketing partner

LIKE SurfKY on Facebook - Click here to LIKE us now.

© Copyright 2015 SurfKY News Group, Inc. All rights reserved. This material may not be published, broadcast, or rewritten without permission. SurfKY News encourages you to share this story on social media.

Posted on 2/2/14

In Other News...

One Injured in Vehicle Roll-Over Accident

NEBO, Ky. (8/1/15) ― A Providence woman was injured in an early morning accident Friday on Nebo Road. According to… Read More

Happenings, Meetings Listed for Following Week

HOPKINS COUNTY, Ky. (08/01/15) ― The following happenings and meetings are scheduled for next week: • First United… Read More

Most Read This Week

July 27, 2015 6025

Death of Central City Man in Dawson Springs Under…

by SurfKY News
July 27, 2015 3806

School System Announces Free Lunch/Breakfast at…

by SurfKY News
July 30, 2015 3470

Webster Man Leads Police on Chase through Parts…

by SurfKY News
July 31, 2015 3444

Miss Hopkins County Fair 2015 Chosen

by Tammy Holloway, SurfKY News
July 28, 2015 2668

Hanson, Owensboro, Bowling Green Youths Win at…

by Tammy Holloway, SurfKY News

Most Read This Month

July 17, 2015 16403

Muhlenberg Most Wanted - Top 10

by SurfKY News
July 23, 2015 15375

UPDATE: Family Confirms Body of Missing Teen…

by Shawn Freels, SurfKY News

Stories Trending Now

August 01, 2015 2287

24th Annual Miss Teen Hopkins County Fair Pageant…

by Tammy Holloway, SurfKY News
August 01, 2015 2150

Little Miss, Mister Hopkins County Fair Chosen

by Tammy Holloway, SurfKY News
August 01, 2015 1566

'Diggers' Return to Find More Hatfield-McCoy…

by SurfKY News
August 01, 2015 1106

Knight Crowned 2015 Miss Pre-Teen Hopkins County…

by Tammy Holloway, SurfKY News
August 01, 2015 956

One Injured in Vehicle Roll-Over Accident

by SurfKY News
August 01, 2015 499

South Korean Automotive Supplier INFAC North…

by SurfKY News
August 01, 2015 482

Who Will Be America's Next President?

by SurfKY News
August 01, 2015 437

Commissioner Comer Honors Kentucky Farmers'…

by SurfKY News
August 01, 2015 420

Keeping the Faith - 'In Scorn of the Consequences'

by SurfKY News